No audio after restart or unlock

Hi Eric, welcome to the forum.
Have you read the troubleshooting list at the top yet?
Which version of FxSound do you have installed?
The latest release is v1.1.26.0 available from fxsound.com as always, and your version number is shown in the Help tab of the Settings menu.
Have you tried adjusting the settings related to automatic switching, or since v1.1.26.0 those related to the Preferred Output Device?
If your issue is related to device switching inside FxSound’s drop-down device selection menu only, then you could also set a customized keyboard shortcut inside the General tab of the Settings to switch devices faster.
If your issue is related to device switching inside Windows Sound Settings: have you tried setting your speakers as the Default Communication Device yet?
And have you disabled all settings related to Exclusive Mode, Enhancements and Hardware Acceleration for all devices (as per the troubleshooting list)?
This is the thread on the new Preferred Output Device feature,

This is the issue on Standby/Sleep Mode,