Does FX Sound work with SoundBlaster Play! 3 audio device?

I have been having problems with FX Sound conflicting with my onboard Realtec audio and had to uninstall it and re-install the driver (again). Big problem. So I bought a SoundBlaster Play! 3 audio device that is a USB (my speakers connect to my headphone jack on a desktop). I can’t get them to work together. I like FX Sound but it doesn’t like to play much…